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Autor: P. Colm Malone
ISBN-13: 9781402066498
Einband: Buch
Seiten: 318
Format: 235x155x mm
Sprache: Englisch
Erscheinungsdatum: 24.01.2008

The Aetiology of Deep Venous Thrombosis

A Critical, Historical and Epistemological Survey
to the Study of Deep Venous Thrombosis.- The Coagulation Cascade and the Consensus Model of DVT.- Hypercoagulability.- Historical Roots.- Coagulation and its Disorders: A History of Haematological Research.- Virchow and the Pathophysiological Tradition in the 19th Century.- The Pathophysiological Tradition after Virchow.- Interrupted Circulation: The 'Stasis' Hypothesis and the Significance of Venous Valves.- Underperfusion of Valve Pockets and the Initiation of DVT.- The Role of Endothelial Hypoxia in DVT.- The Valve Cusp Hypoxia Hypothesis.- Molecular Changes in the Hypoxic Endothelium.- Cadaver Clots or Agonal Thrombi?.
What we now call 'deep venous thrombosis' (DVT) has been elucidated by a diversity of investigative approaches during the past four centuries. The authors of this book survey the history of the field and ask: why has one of these perspectives - the haematological/biochemical - come to dominate research into the causation of DVT during the past 50 years and to exclude alternatives? In answering this question, the authors show that the current consensus model is conceptually flawed.
Autor: P. Colm Malone
ISBN-13:: 9781402066498
ISBN: 140206649X
Erscheinungsjahr: 24.01.2008
Verlag: Springer Netherlands
Seiten: 318
Sprache: Englisch
Sonstiges: Buch, 235x155x mm