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Autor: Stephen M. Roberts
ISBN-13: 9783319190952
Einband: Buch
Seiten: 498
Format: 242x163x26 mm
Sprache: Englisch

Studies on Experimental Toxicology and Pharmacology

Oxidative Stress in Applied Basic Research and Clinical Practice
Part I. Toxicological Mechanisms and Evaluation of Oxidative Stress .- A historical perspective on oxidative stress and intracellular redox control .- An overview of free radicals as causes and consequences of toxicity.- Oxidants, radicals, free radicals, and other bad stuff in mechanisms of toxicity.- Lipid oxidation.- Protein oxidation and toxicology.- Oxidative stress and DNA damage association with carcinogenesis: A truth or a myth?.- Glutathione and thiols .- Reactive oxygen species as initiators and mediators of cellular signaling processes.- Role of oxidative stress in the process of carcinogenesis.- Part II. Agents that produce toxicity - mechanisms and therapeutic interventions .- Isolation of murine adult bone marrow and fetal liver cells for mechanistic assessment of hematotoxicity caused by organic solvents.- Oxidative stress and ethanol toxicity.- Pharmaceutical agents.- Insecticides and herbicides .- Health effects of indoor air pollution due to cooking with biomass fuel.- Outdoor pollutants.- Oxidative Stress and the Inorganic Carcinogens.- UV-induced signaling: Role of reactive oxygen species.- Nanomaterials.- Chemical warfare agents.- Part III. Special topics.- On the biochemistry of antioxidants - current aspects .-Prevention of age-related diseases - Effects of antioxidant supplements.- The neural progenitor cell (NPC) niche in the adult brain provides a target for neurotoxicity - a potential Adverse Outcome Pathway for ROS-induced NPC dysfunction with higher sensitivity during aging..- Oxygen toxicity: From cough to convulsion.- Oxidative stress in reproductive toxicology.- Toxicogenomics-based assessment of xenobiotic-induced oxidative stress.- Aquatic and marine biology.
This book focuses on data describing the roles of free radicals and related reactive species, and antioxidants, in the causes and treatments of diseases, examining both clinical and pre-clinical trials, as well as basic research. The book is divided into sections with chapters on toxicological mechanisms, agents that produce toxicity, and special topics including areas such as antioxidant supplements, oxygen toxicity, toxicogenomics, and marine biology.
Studies on Experimental Toxicology and Pharmacology promotes the concept of using biomarkers of free radical- and reactive species-induced injury as adjuncts to classical laboratory testing and the ability of antioxidants to provide cellular protection. There is increasing evidence that free radicals and other reactive species are causative, or at least supporting factors, that impact organisms and cause numerous tissue disorders.

With contributions from international experts in the field, this volume is a valuable resource for researchers and postgraduate students in toxicology and related fields, as well as clinicians and clinical researchers.
Editiert von: Stephen M. Roberts, James P. Kehrer, Lars-Oliver Klotz
Stephen M. Roberts, Ph.D. is Director of the Center for Environmental & Human Toxicology at the University of Florida, and is a Professor with joint appointments in the College of Veterinary Medicine, College of Medicine, and the College of Public Health and Health Professions. He received his Ph.D. from the University of Utah College of Medicine, and has developed an active research career focusing on mechanisms of toxicity of drugs and chemicals with funding from the National Institutes of Health, the U.S. Environmental Protection Agency, the Department of Defense, and private industry. He has served on a federal scientific advisory committees dealing with matters related to toxicology for the U.S. Department of Health and Human Services, the Food and Drug Administration, and the U.S. Environmental Protection Agency.
Autor: Stephen M. Roberts
ISBN-13:: 9783319190952
ISBN: 3319190954
Verlag: Springer, Berlin, Springer International Publishing, Humana Press
Seiten: 498
Sprache: Englisch
Auflage 1st ed. 2015
Sonstiges: Buch, 242x163x26 mm, 7 Tabellen, 1 Farbtabellen