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Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression

 Buch
Besorgungstitel | Lieferzeit:3-5 Tage I
ISBN-13:
9783540676119
Einband:
Buch
Seiten:
190
Autor:
Martin L. Privalsky
Gewicht:
1050 g
Format:
235x155x mm
Serie:
Vol.254, Current Topics in Microbiology and Immunology
Sprache:
Englisch
Beschreibung:

Molecular Mechanisms of Corepressor Function.- Role of Histone Deacetylase Complexes in the Regulation of Chromatin Metabolism.- Corepressor Proteins and Control of Transcription in Yeast.- Corepressor Proteins in Drosophila Development.- Corepressors and Nuclear Hormone Receptor Function.- Regulation of SMRT and N-CoR Corepressor Function.- Corepressors and Retinoblastoma Protein Function.- Smad Transcriptional Corepressors in TGFß Family Signaling.- Role of Nuclear Receptor Corepressors in Leukemogenesis.
Corepressors are newly discovered assemblies of proteins that play essential roles in eukaryotic gene regulation. Recent discoveries about corepressors have provided new insights into the molecular basis of gene regulation, and have established surprising connections between the mechanisms of action of a wide variety of transcriptional regulators. The reviews in this volume critically discuss the nature, mechanisms of action, and physiological roles of corepressors in a diverse assortment of biological systems. Both basic and clinical investigators will be able to find relevant information. The comprehensive nature of the compilation, and the breadth of the reviews, are intended to provide the reader with an excellent introduction to the newly emergent and rapidly-growing field of corepressor research. A valuable and detailed reference guide.

Molecular Mechanisms of Corepressor Function.- Role of Histone Deacetylase Complexes in the Regulation of Chromatin Metabolism.- Corepressor Proteins and Control of Transcription in Yeast.- Corepressor Proteins in Drosophila Development.- Corepressors and Nuclear Hormone Receptor Function.- Regulation of SMRT and N-CoR Corepressor Function.- Corepressors and Retinoblastoma Protein Function.- Smad Transcriptional Corepressors in TGFß Family Signaling.- Role of Nuclear Receptor Corepressors in Leukemogenesis.
Corepressors are newly discovered assemblies of proteins that play essential roles in eukaryotic gene regulation. Recent discoveries about corepressors have provided new insights into the molecular basis of gene regulation, and have established surprising connections between the mechanisms of action of a wide variety of transcriptional regulators. The reviews in this volume critically discuss the nature, mechanisms of action, and physiological roles of corepressors in a diverse assortment of biological systems. Both basic and clinical investigators will be able to find relevant information. The comprehensive nature of the compilation, and the breadth of the reviews, are intended to provide the reader with an excellent introduction to the newly emergent and rapidly-growing field of corepressor research. A valuable and detailed reference guide.
Autor: Martin L. Privalsky
ISBN-13:: 9783540676119
ISBN: 3540676112
Verlag: Springer, Berlin
Gewicht: 1050g
Seiten: 190
Sprache: Englisch
Auflage Repr. d. Ausg. v. 2000
Sonstiges: Buch, 235x155x mm, 2 Tabellen