Der Artikel ist weiterhin als ^^OTHERCONDITION^^ verfügbar.
Autor: Xiao-Yu Sun
ISBN-13: 9783642442117
Einband: Previously published in hardcover
Seiten: 222
Gewicht: 367 g
Format: 235x155x mm
Sprache: Englisch

Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B

Springer Theses
This thesis presents the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. It also details a biomimetic method for converting Plakortide E methyl ester to plakortone B.
99
Introduction.- Results and Discussion.- Conclusion.- Experimental Section.- References.- Appendix I.- Appendix II.
In his thesis, Xiaoyu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiaoyu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery.
Autor: Xiao-Yu Sun
ISBN-13:: 9783642442117
ISBN: 3642442110
Verlag: Springer, Berlin
Gewicht: 367g
Seiten: 222
Sprache: Englisch
Auflage 2012
Sonstiges: Taschenbuch, 235x155x mm, 296 SW-Abb., 12 Farbabb.,